Expanding Fragmentome Technology
AI Blood Test Detects Early Liver Disease
Johns Hopkins researchers use liquid biopsy technology to identify fibrosis and cirrhosis before symptoms appear.

A medical researcher holds a blood sample vial in a laboratory, with digital screens showing complex DNA data and AI analysis symbols.
Photo: Avantgarde News
Researchers at Johns Hopkins developed an AI-driven blood test to detect early-stage liver disease [1][2]. The liquid biopsy scans DNA fragments to identify markers of liver fibrosis and cirrhosis years before symptoms develop [1][3]. This marks the first time fragmentome technology has been applied to chronic non-cancer diseases [2]. Current diagnostic methods often require invasive biopsies or imaging that may miss early signs of scarring [2]. The new AI model analyzes "fragmentomes," which are patterns of cell-free DNA released into the bloodstream [3]. This approach could provide a scalable way to screen millions of people at risk for chronic liver conditions [1].
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Sources
- 1.↗
sciencedaily.com
https://www.sciencedaily.com/releases/2026/03/260305223204.htm
- 2.↗
hopkinsmedicine.org
https://www.hopkinsmedicine.org/news/newsroom/news-releases/2026/03/ai-based-liquid-biopsy-may-detect-liver-fibrosis-cirrhosis-and-chronic-disease-signals
- 3.↗
bioengineer.org
https://bioengineer.org/ai-powered-liquid-biopsy-shows-promise-in-detecting-liver-fibrosis-cirrhosis-and-chronic-disease-indicators/
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About the author
Avantgarde News Desk covers expanding fragmentome technology and editorial analysis for Avantgarde News.


